PLUMED allows you to run a number of enhanced sampling algorithms. The list of enhanced sampling algorithms contained in PLUMED is as follows:

ABMD	Adds a ratchet-and-pawl like restraint on one or more variables.
BIASVALUE	Takes the value of one variable and use it as a bias
EXTENDED_LAGRANGIAN	Add extended Lagrangian.
EXTERNAL	Calculate a restraint that is defined on a grid that is read during start up
LOWER_WALLS	Defines a wall for the value of one or more collective variables, which limits the region of the phase space accessible during the simulation.
MAXENT	Add a linear biasing potential on one or more variables \(f_{i}\left(\boldsymbol{x}\right)\) satisfying the maximum entropy principle as proposed in Ref. [2] .
METAD	Used to performed MetaDynamics on one or more collective variables.
MOVINGRESTRAINT	Add a time-dependent, harmonic restraint on one or more variables.
PBMETAD	Used to performed Parallel Bias MetaDynamics.
RESTRAINT	Adds harmonic and/or linear restraints on one or more variables.
UPPER_WALLS	Defines a wall for the value of one or more collective variables, which limits the region of the phase space accessible during the simulation.

In addition to the keywords above, by enabling optional modules you can access to the following keywords:

DRR	(from Extended-System Adaptive Biasing Force module) Used to performed extended-system adaptive biasing force(eABF) [60] methodon one or more collective variables. This method is alsocalled dynamic reference restraining(DRR) [98] .
EDS	(from Experiment Directed Simulation module) Add a linear bias on a set of observables.
METAINFERENCE	(from PLUMED-ISDB module) Calculates the Metainference energy for a set of experimental data.
RESCALE	(from PLUMED-ISDB module) Rescales the value of an another action, being a Collective Variable or a Bias.
VES_LINEAR_EXPANSION	(from Variationally Enhanced Sampling (VES code) module) Linear basis set expansion bias.

Methods, such as METAD or PBMETAD, that work by introducing a history dependent bias can be restarted using the RESTART keyword